Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of Chronic Lymphocytic Leukemia

Similar to human CLL, the de novo NZB mouse model has a genetically determined age-associated increase in malignant B-1 clones and decreased expression of microRNAs miR-15a and miR-16 in B-1 cells. In the present study, lentiviral vectors were employed in vivo to restore miR-15a/16, and both the sho...

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Detalles Bibliográficos
Autores principales: Salerno, Erica, Kasar, Siddha, Yuan, Yao, Vollenweider, Daniel, Laurindo, Maria Fernanda, Fernandes, Helen, Bonci, Désirée, Addario, Antonio, Mazzella, Fermina, Raveche, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516396/
https://www.ncbi.nlm.nih.gov/pubmed/21881595
http://dx.doi.org/10.1038/gene.2011.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516396/
https://www.ncbi.nlm.nih.gov/pubmed/21881595
http://dx.doi.org/10.1038/gene.2011.58

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