An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3′-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary l...

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Detalles Bibliográficos
Autores principales: Vlachakis, Dimitrios, Pavlopoulou, Athanasia, Tsiliki, Georgia, Komiotis, Dimitri, Stathopoulos, Constantinos, Balatsos, Nikolaos A. A., Kossida, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516499/
https://www.ncbi.nlm.nih.gov/pubmed/23236441
http://dx.doi.org/10.1371/journal.pone.0051113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516499/
https://www.ncbi.nlm.nih.gov/pubmed/23236441
http://dx.doi.org/10.1371/journal.pone.0051113

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