The P2Y(12) Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y(12)/G(i)-Dependent Mechanism

BACKGROUND: ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Gα(q)-coupled) and P2Y(12) (Gα(i)-coupled). P2Y(12) plays a critical role in platelet activation and thrombosis. Adenosine-based P2Y(12) antagonists, 2-methyl...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiang, Binggang, Zhang, Guoying, Ren, Hongmei, Sunkara, Manjula, Morris, Andrew J., Gartner, T. Kent, Smyth, Susan S., Li, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516503/
https://www.ncbi.nlm.nih.gov/pubmed/23236426
http://dx.doi.org/10.1371/journal.pone.0051037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516503/
https://www.ncbi.nlm.nih.gov/pubmed/23236426
http://dx.doi.org/10.1371/journal.pone.0051037

Ejemplares similares