Cargando…

The P2Y(12) Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y(12)/G(i)-Dependent Mechanism

BACKGROUND: ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Gα(q)-coupled) and P2Y(12) (Gα(i)-coupled). P2Y(12) plays a critical role in platelet activation and thrombosis. Adenosine-based P2Y(12) antagonists, 2-methyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiang, Binggang, Zhang, Guoying, Ren, Hongmei, Sunkara, Manjula, Morris, Andrew J., Gartner, T. Kent, Smyth, Susan S., Li, Zhenyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516503/ https://www.ncbi.nlm.nih.gov/pubmed/23236426 http://dx.doi.org/10.1371/journal.pone.0051037

Ejemplares similares

Feasibility and safety of cangrelor in patients with suboptimal P2Y(12) inhibition undergoing percutaneous coronary intervention: the Dutch Cangrelor registry
por: Selvarajah, Abi, et al.
Publicado: (2021)

Feasibility and safety of cangrelor in patients with suboptimal P2Y(12) inhibition undergoing percutaneous coronary intervention: rationale of the Dutch Cangrelor Registry
por: Selvarajah, A., et al.
Publicado: (2021)

P2Y(12) Receptor Function and Response to Cangrelor in Neonates With Cyanotic Congenital Heart Disease
por: Kaza, Elisabeth A., et al.
Publicado: (2017)

Cardioprotective Properties of the Platelet P2Y(12) Receptor Inhibitor, Cangrelor: Protective in Diabetics and Reliant Upon the Presence of Blood
por: Bell, R. M., et al.
Publicado: (2015)

Safety of cangrelor and transition to oral P2Y(12) inhibitors in patients undergoing percutaneous coronary intervention: the ARCANGELO study
por: De Luca, Leonardo, et al.
Publicado: (2023)

Platelet P2Y12 Is Involved in Murine Pulmonary Metastasis
por: Wang, Yanhua, et al.
Publicado: (2013)

Cangrelor Use Patterns and Transition to Oral P2Y(12) Inhibitors Among Patients With Myocardial Infarction: Initial Results From the CAMEO Registry
por: Rymer, Jennifer A., et al.
Publicado: (2022)

P2Y12 inhibitors for the neurointerventionalist
por: Borchert, Robin J, et al.
Publicado: (2021)

Analysis of the Financial Impact of Using Cangrelor on the Safety and Efficacy Outcomes in Patients Undergoing Percutaneous Coronary Intervention in Whom Oral Therapy with P2Y(12) Inhibitors is Not Feasible or Desirable, in Spain
por: Lizano-Díez, Irene, et al.
Publicado: (2021)

P2Y(12) Receptors in Tumorigenesis and Metastasis
por: Ballerini, Patrizia, et al.
Publicado: (2018)

Pharmacokinetic/pharmacodynamic modeling of drug interactions at the P2Y(12) receptor between selatogrel and oral P2Y(12) antagonists
por: Henrich, Andrea, et al.
Publicado: (2021)

D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function
por: Dangelmaier, Carol, et al.
Publicado: (2022)

GRK2 regulates ADP signaling in platelets via P2Y(1) and P2Y(12)
por: Zhao, Xuefei, et al.
Publicado: (2022)

Antiplatelet Therapy in ACS Patients: Comparing Appropriate P2Y12 Inhibition by Clopidogrel to the Use of New P2Y12 Inhibitors
por: Ristorto, Jessica, et al.
Publicado: (2018)

P2Y12 platelet inhibition in clinical practice
por: Damman, Peter, et al.
Publicado: (2011)

Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y(12) receptor and is correlated with protein expression of P2Y(12)
por: Braun, Oscar Ö, et al.
Publicado: (2006)

Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y(1) and P2Y(12) Receptors
por: Wu, Chang-Chieh, et al.
Publicado: (2016)

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms
por: Fekete, Rebeka, et al.
Publicado: (2018)

Structural insights into signal transduction of the purinergic receptors P2Y(1)R and P2Y(12)R
por: Li, Beibei, et al.
Publicado: (2022)

Characterisation of P2Y(12) Receptor Responsiveness to Cysteinyl Leukotrienes
por: Foster, Holly R., et al.
Publicado: (2013)

Agonist-bound structure of the human P2Y(12) receptor
por: Zhang, Jin, et al.
Publicado: (2014)

P2Y(12) Receptor on the Verge of a Neuroinflammatory Breakdown
por: Amadio, Susanna, et al.
Publicado: (2014)

To Pretreat or Not to Pretreat (With Oral P2Y12 Antagonists)? That is the Question
por: Lowenstern, Angela, et al.
Publicado: (2017)

P2Y(12) Inhibition beyond Thrombosis: Effects on Inflammation
por: Mansour, Alexandre, et al.
Publicado: (2020)

The Safeguarding Microglia: Central Role for P2Y(12) Receptors
por: Lin, Si-Si, et al.
Publicado: (2021)

Aspirin and P2Y12 inhibitors in treating COVID-19
por: Khalaji, Amirmohammad, et al.
Publicado: (2023)

P2Y12 receptor gene polymorphisms are associated with epilepsy
por: Wang, Qi, et al.
Publicado: (2022)

Diagnostic and therapeutic value of P2Y12R in epilepsy
por: Chen, Xiang, et al.
Publicado: (2023)

Structural and functional evolution of the P2Y(12)-like receptor group
por: Schöneberg, Torsten, et al.
Publicado: (2007)

P2Y(12) Platelet Receptors: Importance in Percutaneous Coronary Intervention
por: Falcão, Felipe Jose de Andrade, et al.
Publicado: (2013)

The effect of P2Y12 receptor inhibition in chronic inflammatory pain
por: Bekő, Katinka, et al.
Publicado: (2015)

P2Y12 expression and function in alternatively activated human microglia
por: Moore, Craig S., et al.
Publicado: (2015)

P2Y12 expression and function in alternatively activated human microglia
Publicado: (2015)

Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets
por: Bijak, Michal, et al.
Publicado: (2018)

P2Y12 inhibition after thrombotic thrombocytopenic purpura remission
por: Kahraman, Serkan, et al.
Publicado: (2017)

Loss of P2Y12 Has Behavioral Effects in the Adult Mouse
por: Lowery, Rebecca L., et al.
Publicado: (2021)

P2Y12 blocker monotherapy after percutaneous coronary intervention
por: Verheugt, F. W. A., et al.
Publicado: (2021)

P2Y(12) Inhibitor Monotherapy after Percutaneous Coronary Intervention
por: Zhou, Xuan, et al.
Publicado: (2022)

Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation
por: Su, Chunyan, et al.
Publicado: (2023)

Antiplatelet Activity, P2Y(1) and P2Y(12) Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P(1),P(4)-dithio-P(2),P(3)-chloromethylenetetraphosphate
por: Chang, Hung, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6ahd79fo5l2gq5fi0ffvhnp27n