Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction

Long-duration comparative molecular dynamics simulations of the DNA-topoisomerase binary and DNA-topoisomerase-indenoisoquinoline ternary complexes have been carried out. The analyses demonstrated the role of the drug in conformationally stabilizing the protein-DNA interaction. In detail, the protei...

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Detalles Bibliográficos
Autores principales: Mancini, Giordano, D’Annessa, Ilda, Coletta, Andrea, Chillemi, Giovanni, Pommier, Yves, Cushman, Mark, Desideri, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516564/
https://www.ncbi.nlm.nih.gov/pubmed/23236483
http://dx.doi.org/10.1371/journal.pone.0051354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516564/
https://www.ncbi.nlm.nih.gov/pubmed/23236483
http://dx.doi.org/10.1371/journal.pone.0051354

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