A Global Comparison of the Human and T. brucei Degradomes Gives Insights about Possible Parasite Drug Targets

We performed a genome-level computational study of sequence and structure similarity, the latter using crystal structures and models, of the proteases of Homo sapiens and the human parasite Trypanosoma brucei. Using sequence and structure similarity networks to summarize the results, we constructed...

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Detalles Bibliográficos
Autores principales: Mashiyama, Susan T., Koupparis, Kyriacos, Caffrey, Conor R., McKerrow, James H., Babbitt, Patricia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516576/
https://www.ncbi.nlm.nih.gov/pubmed/23236535
http://dx.doi.org/10.1371/journal.pntd.0001942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516576/
https://www.ncbi.nlm.nih.gov/pubmed/23236535
http://dx.doi.org/10.1371/journal.pntd.0001942

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