Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter

Interleukin-17A (IL-17A) is the signature cytokine produced by Th17 CD4(+) T cells and has been tightly linked to autoimmune pathogenesis. In particular, the transcription factors NFAT and RORγt are known to activate Il17a transcription, although the detailed mechanism of action remains incompletely...

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Detalles Bibliográficos
Autores principales: Hermann-Kleiter, Natascha, Meisel, Marlies, Fresser, Friedrich, Thuille, Nikolaus, Müller, Mathias, Roth, Lukas, Katopodis, Andreas, Baier, Gottfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516707/
https://www.ncbi.nlm.nih.gov/pubmed/22921335
http://dx.doi.org/10.1016/j.jaut.2012.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516707/
https://www.ncbi.nlm.nih.gov/pubmed/22921335
http://dx.doi.org/10.1016/j.jaut.2012.07.007

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