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A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors

[Image: see text] Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through...

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Detalles Bibliográficos
Autores principales: Brant, Michael G., Wulff, Jeremy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516865/
https://www.ncbi.nlm.nih.gov/pubmed/23181823
http://dx.doi.org/10.1021/ol3027939