Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α

BACKGROUND: One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of HER2 is used for therapy of HER2-overexpressing mammary tumors. However, ma...

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Detalles Bibliográficos
Autores principales: Ceran, Ceyhan, Cokol, Murat, Cingoz, Sultan, Tasan, Ipek, Ozturk, Mehmet, Yagci, Tamer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517359/
https://www.ncbi.nlm.nih.gov/pubmed/23033967
http://dx.doi.org/10.1186/1471-2407-12-450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517359/
https://www.ncbi.nlm.nih.gov/pubmed/23033967
http://dx.doi.org/10.1186/1471-2407-12-450

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