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Escherichia coli RecG functionally suppresses human Bloom syndrome phenotypes

Defects in the human BLM gene cause Bloom syndrome, notable for early development of tumors in a broad variety of tissues. On the basis of sequence similarity, BLM has been identified as one of the five human homologs of RecQ from Escherichia coli. Nevertheless, biochemical characterization of the B...

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Detalles Bibliográficos
Autores principales: Killen, Michael W, Stults, Dawn M, Wilson, William A, Pierce, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517418/
https://www.ncbi.nlm.nih.gov/pubmed/23110454
http://dx.doi.org/10.1186/1471-2199-13-33