New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53(−/−) mice by delaying carcinogenesis

The nutrient-sensing mTOR (mammalian Target of Rapamycin) pathway regulates cellular metabolism, growth functions, and proliferation and is involved in age-related diseases including cancer, type 2 diabetes, neurodegeneration and cardiovascular disease. The inhibition of mTOR by rapamycin, or calori...

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Detalles Bibliográficos
Autores principales: Comas, Maria, Toshkov, Ilia, Kuropatwinski, Karen K., Chernova, Olga B., Polinsky, Alexander, Blagosklonny, Mikhail V., Gudkov, Andrei V., Antoch, Marina P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517942/
https://www.ncbi.nlm.nih.gov/pubmed/23117593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517942/
https://www.ncbi.nlm.nih.gov/pubmed/23117593

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