The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be b...

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Detalles Bibliográficos
Autores principales: Price, John C., Khambatta, Cyrus F., Li, Kelvin W., Bruss, Matthew D., Shankaran, Mahalakshmi, Dalidd, Marcy, Floreani, Nicholas A., Roberts, Lindsay S., Turner, Scott M., Holmes, William E., Hellerstein, Marc K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518108/
https://www.ncbi.nlm.nih.gov/pubmed/22984287
http://dx.doi.org/10.1074/mcp.M112.021204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518108/
https://www.ncbi.nlm.nih.gov/pubmed/22984287
http://dx.doi.org/10.1074/mcp.M112.021204

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