Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC(50) values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined throug...

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Detalles Bibliográficos
Autores principales: Soumyanarayanan, Uttara, Bhat, Varadaraj G, Kar, Sidhartha S, Mathew, Jesil A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518143/
https://www.ncbi.nlm.nih.gov/pubmed/22691177
http://dx.doi.org/10.1186/2191-2858-2-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518143/
https://www.ncbi.nlm.nih.gov/pubmed/22691177
http://dx.doi.org/10.1186/2191-2858-2-23

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