Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC(50) values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined throug...

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Autores principales: Soumyanarayanan, Uttara, Bhat, Varadaraj G, Kar, Sidhartha S, Mathew, Jesil A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518143/
https://www.ncbi.nlm.nih.gov/pubmed/22691177
http://dx.doi.org/10.1186/2191-2858-2-23
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author Soumyanarayanan, Uttara
Bhat, Varadaraj G
Kar, Sidhartha S
Mathew, Jesil A
author_facet Soumyanarayanan, Uttara
Bhat, Varadaraj G
Kar, Sidhartha S
Mathew, Jesil A
author_sort Soumyanarayanan, Uttara
collection PubMed
description Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC(50) values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship of the compounds in comparison with monastrol.
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spelling pubmed-35181432012-12-12 Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study Soumyanarayanan, Uttara Bhat, Varadaraj G Kar, Sidhartha S Mathew, Jesil A Org Med Chem Lett Original Article Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC(50) values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship of the compounds in comparison with monastrol. Springer 2012-06-12 /pmc/articles/PMC3518143/ /pubmed/22691177 http://dx.doi.org/10.1186/2191-2858-2-23 Text en Copyright ©2012 Soumyanarayanan et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Soumyanarayanan, Uttara
Bhat, Varadaraj G
Kar, Sidhartha S
Mathew, Jesil A
Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title_full Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title_fullStr Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title_full_unstemmed Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title_short Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study
title_sort monastrol mimic biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against hepg2 and hela cell lines and molecular modeling study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518143/
https://www.ncbi.nlm.nih.gov/pubmed/22691177
http://dx.doi.org/10.1186/2191-2858-2-23
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