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Munc13 controls the location and efficiency of dense-core vesicle release in neurons

Neuronal dense-core vesicles (DCVs) contain diverse cargo crucial for brain development and function, but the mechanisms that control their release are largely unknown. We quantified activity-dependent DCV release in hippocampal neurons at single vesicle resolution. DCVs fused preferentially at syna...

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Detalles Bibliográficos
Autores principales: van de Bospoort, Rhea, Farina, Margherita, Schmitz, Sabine K., de Jong, Arthur, de Wit, Heidi, Verhage, Matthijs, Toonen, Ruud F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518216/
https://www.ncbi.nlm.nih.gov/pubmed/23229896
http://dx.doi.org/10.1083/jcb.201208024