Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

The mitotic checkpoint protein Bub1 is essential for embryogenesis and survival of proliferating cells, and bidirectional deviations from its normal level of expression cause chromosome missegregation, aneuploidy, and cancer predisposition in mice. To provide insight into the physiological significa...

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Detalles Bibliográficos
Autores principales: Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518220/
https://www.ncbi.nlm.nih.gov/pubmed/23209306
http://dx.doi.org/10.1083/jcb.201205115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518220/
https://www.ncbi.nlm.nih.gov/pubmed/23209306
http://dx.doi.org/10.1083/jcb.201205115

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