A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

A critical event in protein translocation across the endoplasmic reticulum is the structural transition between the closed and open conformations of Sec61, the eukaryotic translocation channel. Channel opening allows signal sequence insertion into a gap between the N- and C-terminal halves of Sec61....

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Detalles Bibliográficos
Autores principales: Trueman, Steven F., Mandon, Elisabet C., Gilmore, Reid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518225/
https://www.ncbi.nlm.nih.gov/pubmed/23229898
http://dx.doi.org/10.1083/jcb.201207163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518225/
https://www.ncbi.nlm.nih.gov/pubmed/23229898
http://dx.doi.org/10.1083/jcb.201207163

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