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A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function
A critical event in protein translocation across the endoplasmic reticulum is the structural transition between the closed and open conformations of Sec61, the eukaryotic translocation channel. Channel opening allows signal sequence insertion into a gap between the N- and C-terminal halves of Sec61....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518225/ https://www.ncbi.nlm.nih.gov/pubmed/23229898 http://dx.doi.org/10.1083/jcb.201207163 |