Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation

Pluripotent embryonic stem cells (ESCs) have a shortened cell cycle that enables their rapid proliferation. The ESC-specific miR-290 and miR-302 microRNA families promote proliferation whereas let-7 microRNAs inhibit self-renewal and promote cell differentiation. Lin28 suppresses let-7 expression in...

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Detalles Bibliográficos
Autores principales: Chang, Hao-Ming, Martinez, Natalia J., Thornton, James E., Gregory, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518406/
https://www.ncbi.nlm.nih.gov/pubmed/22735451
http://dx.doi.org/10.1038/ncomms1909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518406/
https://www.ncbi.nlm.nih.gov/pubmed/22735451
http://dx.doi.org/10.1038/ncomms1909

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