Functional differences between low- and high-affinity CD8(+) T cells in the tumor environment

Weak T-cell antigen receptor (TCR)-ligand interactions are sufficient to activate naïve CD8(+) T cells, but generally do not result in tumor eradication. How differences in TCR affinity affect the regulation of T-cell function in an immunosuppressive tumor environment has not been investigated. We h...

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Detalles Bibliográficos
Autores principales: Bos, Rinke, Marquardt, Kristi L., Cheung, Jocelyn, Sherman, Linda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518496/
https://www.ncbi.nlm.nih.gov/pubmed/23243587
http://dx.doi.org/10.4161/onci.21285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518496/
https://www.ncbi.nlm.nih.gov/pubmed/23243587
http://dx.doi.org/10.4161/onci.21285

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