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Depletion of phagocytic myeloid cells triggers spontaneous T cell- and NK cell-dependent antitumor activity

Depletion of tumor associated macrophages and inhibition of tumor angiogenesis have been invoked as the principle mechanisms underlying the antitumor activity of liposomal clodronate (LC). However, previous studies have not examined the effects of LC on systemic antitumor immunity. Here, we used mou...

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Detalles Bibliográficos
Autores principales: Guth, Amanda M., Hafeman, Scott D., Dow, Steven W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518497/
https://www.ncbi.nlm.nih.gov/pubmed/23243588
http://dx.doi.org/10.4161/onci.21317