TLR2 ligation protects effector T cells from regulatory T-cell mediated suppression and repolarizes T helper responses following MVA-based cancer immunotherapy

Cancer immunotherapy is hampered by the immunosuppression maintained by regulatory T cells (Tregs) in tumor-bearing hosts. Stimulation of the Toll-like receptor 2 (TLR2) by Pam3Cys is known to affect Treg-mediated suppression. We found that Pam3Cys increases the proliferation of both CD4(+) effector...

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Detalles Bibliográficos
Autores principales: Amiset, Laurent, Fend, Laetitia, Gatard-Scheikl, Tania, Rittner, Karola, Duong, Vanessa, Rooke, Ronald, Muller, Sylviane, Bonnefoy, Jean-Yves, Préville, Xavier, Haegel, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518499/
https://www.ncbi.nlm.nih.gov/pubmed/23243590
http://dx.doi.org/10.4161/onci.21479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518499/
https://www.ncbi.nlm.nih.gov/pubmed/23243590
http://dx.doi.org/10.4161/onci.21479

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