Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

Recent evidence demonstrates that the efficacy of conventional anticancer therapies including chemotherapy requires a functional immune system. Here, we addressed the possibility that the antitumor effect of a selective Smoothened antagonist and Hedgehog (Hh) pathway inhibitor (LDE225), a promising...

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Detalles Bibliográficos
Autores principales: Paget, Christophe, Duret, Helene, Ngiow, Shin Foong, Kansara, Maya, Thomas, David M., Smyth, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518504/
https://www.ncbi.nlm.nih.gov/pubmed/23243595
http://dx.doi.org/10.4161/onci.21680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518504/
https://www.ncbi.nlm.nih.gov/pubmed/23243595
http://dx.doi.org/10.4161/onci.21680

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