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Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

Recent evidence demonstrates that the efficacy of conventional anticancer therapies including chemotherapy requires a functional immune system. Here, we addressed the possibility that the antitumor effect of a selective Smoothened antagonist and Hedgehog (Hh) pathway inhibitor (LDE225), a promising...

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Detalles Bibliográficos
Autores principales:	Paget, Christophe, Duret, Helene, Ngiow, Shin Foong, Kansara, Maya, Thomas, David M., Smyth, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518504/ https://www.ncbi.nlm.nih.gov/pubmed/23243595 http://dx.doi.org/10.4161/onci.21680

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