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Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy

A decade of collective work by tumor immunologists has led to improved large scale generation, maturation, antigen loading and administration of dendritic cells (DCs) to cancer patients, promoting enhanced antitumor activity. We alleviated the HLA-restriction in DC therapy and demonstrated that it i...

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Detalles Bibliográficos
Autores principales: Van Nuffel, An M.T., Wilgenhof, Sofie, Thielemans, Kris, Bonehill, Aude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518513/
https://www.ncbi.nlm.nih.gov/pubmed/23243604
http://dx.doi.org/10.4161/onci.20926