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Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis
Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518520/ https://www.ncbi.nlm.nih.gov/pubmed/23243611 http://dx.doi.org/10.4161/onci.21060 |