Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis

Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to...

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Detalles Bibliográficos
Autores principales: Hurchla, Michelle A., Weilbaecher, Katherine N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518520/
https://www.ncbi.nlm.nih.gov/pubmed/23243611
http://dx.doi.org/10.4161/onci.21060
Descripción
Sumario:Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.

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