Cargando…
Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis
Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518520/ https://www.ncbi.nlm.nih.gov/pubmed/23243611 http://dx.doi.org/10.4161/onci.21060 |
| _version_ | 1782252568102043648 |
|---|---|
| author | Hurchla, Michelle A. Weilbaecher, Katherine N. |
| author_facet | Hurchla, Michelle A. Weilbaecher, Katherine N. |
| author_sort | Hurchla, Michelle A. |
| collection | PubMed |
| description | Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells. |
| format | Online Article Text |
| id | pubmed-3518520 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35185202012-12-14 Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis Hurchla, Michelle A. Weilbaecher, Katherine N. Oncoimmunology Author's View Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518520/ /pubmed/23243611 http://dx.doi.org/10.4161/onci.21060 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Hurchla, Michelle A. Weilbaecher, Katherine N. Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title | Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title_full | Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title_fullStr | Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title_full_unstemmed | Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title_short | Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| title_sort | hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518520/ https://www.ncbi.nlm.nih.gov/pubmed/23243611 http://dx.doi.org/10.4161/onci.21060 |
| work_keys_str_mv | AT hurchlamichellea hedgehogtargetedtherapeuticsuncoupletheviciouscycleofbonemetastasis AT weilbaecherkatherinen hedgehogtargetedtherapeuticsuncoupletheviciouscycleofbonemetastasis |