Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boo...

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Detalles Bibliográficos
Autores principales: Sihto, Harri, Joensuu, Heikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518523/
https://www.ncbi.nlm.nih.gov/pubmed/23243614
http://dx.doi.org/10.4161/onci.21120
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author Sihto, Harri
Joensuu, Heikki
author_facet Sihto, Harri
Joensuu, Heikki
author_sort Sihto, Harri
collection PubMed
description An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC.
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spelling pubmed-35185232012-12-14 Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer Sihto, Harri Joensuu, Heikki Oncoimmunology Author's View An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518523/ /pubmed/23243614 http://dx.doi.org/10.4161/onci.21120 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sihto, Harri
Joensuu, Heikki
Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title_full Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title_fullStr Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title_full_unstemmed Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title_short Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
title_sort tumor-infiltrating lymphocytes and outcome in merkel cell carcinoma, a virus-associated cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518523/
https://www.ncbi.nlm.nih.gov/pubmed/23243614
http://dx.doi.org/10.4161/onci.21120
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AT joensuuheikki tumorinfiltratinglymphocytesandoutcomeinmerkelcellcarcinomaavirusassociatedcancer

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