HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates

Constitutively stabilized HSP90 client proteins are crucial for cancer cell survival and proliferation. Thus, despite—or perhaps because of—their pleiotropic effects on variety of critical oncoproteins, HSP90 inhibitors represent a promising new class of anticancer drugs. We identified MIF as an ess...

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Detalles Bibliográficos
Autores principales: Schulz, Ramona, Dobbelstein, Matthias, Moll, Ute M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518525/
https://www.ncbi.nlm.nih.gov/pubmed/23243616
http://dx.doi.org/10.4161/onci.21173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518525/
https://www.ncbi.nlm.nih.gov/pubmed/23243616
http://dx.doi.org/10.4161/onci.21173

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