A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

Live, attenuated RNA virus vaccines are efficacious but subject to reversion to virulence. Among RNA viruses, replication fidelity is recognized as a key determinant of virulence and escape from antiviral therapy; increased fidelity is attenuating for some viruses. Coronavirus (CoV) replication fide...

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Detalles Bibliográficos
Autores principales: Graham, Rachel L, Becker, Michelle M, Eckerle, Lance D, Bolles, Meagan, Denison, Mark R, Baric, Ralph S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518599/
https://www.ncbi.nlm.nih.gov/pubmed/23142821
http://dx.doi.org/10.1038/nm.2972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518599/
https://www.ncbi.nlm.nih.gov/pubmed/23142821
http://dx.doi.org/10.1038/nm.2972

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