Host gene-encoded severe lung TB: from genes to potential pathways

We are reporting that the two-locus genotype -2518 MCP-1 GG -1607 MMP-1 2G/2G promotes the expression of hyper-inflammation in response to M. tuberculosis infection, inducing extensive tissue damage and severe TB disease. Carriers of this two-locus genotype have a 13-fold higher chance of developing...

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Detalles Bibliográficos
Autores principales: Ganachari, Malathesha, Guio, Heinner, Zhao, Nianxi, Flores-Villanueva, Pedro O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518758/
https://www.ncbi.nlm.nih.gov/pubmed/22992722
http://dx.doi.org/10.1038/gene.2012.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518758/
https://www.ncbi.nlm.nih.gov/pubmed/22992722
http://dx.doi.org/10.1038/gene.2012.39

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