Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases. PARG deficiency leads to cell death whilst PARG depletion causes sensitisation to certain DNA dam...

Descripción completa

Detalles Bibliográficos
Autores principales: Tucker, Julie A., Bennett, Neil, Brassington, Claire, Durant, Stephen T., Hassall, Giles, Holdgate, Geoff, McAlister, Mark, Nissink, J. Willem M., Truman, Caroline, Watson, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519477/
https://www.ncbi.nlm.nih.gov/pubmed/23251397
http://dx.doi.org/10.1371/journal.pone.0050889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519477/
https://www.ncbi.nlm.nih.gov/pubmed/23251397
http://dx.doi.org/10.1371/journal.pone.0050889

Ejemplares similares