Nullbasic, a Potent Anti-HIV Tat Mutant, Induces CRM1-Dependent Disruption of HIV Rev Trafficking

Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, estab...

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Detalles Bibliográficos
Autores principales: Lin, Min-Hsuan, Sivakumaran, Haran, Apolloni, Ann, Wei, Ting, Jans, David A., Harrich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519632/
https://www.ncbi.nlm.nih.gov/pubmed/23251541
http://dx.doi.org/10.1371/journal.pone.0051466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519632/
https://www.ncbi.nlm.nih.gov/pubmed/23251541
http://dx.doi.org/10.1371/journal.pone.0051466

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