Pharmacophore generation and atom-based 3D-QSAR of N-iso-propyl pyrrole-based derivatives as HMG-CoA reductase inhibitors

BACKGROUND: Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity and account for nearly 30% of all deaths each year worldwide. High levels of cholesterol are an important risk factor for coronary heart disease. The blockage of 3-hydroxy-3-methylg...

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Detalles Bibliográficos
Autores principales: Teli, Mahesh Kumar, K, Rajanikant G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519668/
https://www.ncbi.nlm.nih.gov/pubmed/22747771
http://dx.doi.org/10.1186/2191-2858-2-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519668/
https://www.ncbi.nlm.nih.gov/pubmed/22747771
http://dx.doi.org/10.1186/2191-2858-2-25

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