Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3

BACKGROUND: Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of inhibitors. To date, only a few series of non-peptide inhibitors have been des...

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Detalles Bibliográficos
Autores principales: Samiulla, Dodheri Syed, Naidu, Andra, Rao, Gummadi Venkateshwar, Ramachandra, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519673/
https://www.ncbi.nlm.nih.gov/pubmed/22794498
http://dx.doi.org/10.1186/2191-2858-2-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519673/
https://www.ncbi.nlm.nih.gov/pubmed/22794498
http://dx.doi.org/10.1186/2191-2858-2-27

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