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Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3
BACKGROUND: Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of inhibitors. To date, only a few series of non-peptide inhibitors have been des...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519673/ https://www.ncbi.nlm.nih.gov/pubmed/22794498 http://dx.doi.org/10.1186/2191-2858-2-27 |