Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

BACKGROUND: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the distribution of the MDM2 polymorphisms SNP309T>G and the recently discovered SNP28...

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Detalles Bibliográficos
Autores principales: Bjørnslett, Merete, Knappskog, Stian, Lønning, Per Eystein, Dørum, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519699/
https://www.ncbi.nlm.nih.gov/pubmed/23039163
http://dx.doi.org/10.1186/1471-2407-12-454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519699/
https://www.ncbi.nlm.nih.gov/pubmed/23039163
http://dx.doi.org/10.1186/1471-2407-12-454

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