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Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling
BACKGROUND: Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhib...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519737/ https://www.ncbi.nlm.nih.gov/pubmed/22898544 http://dx.doi.org/10.1186/1742-2094-9-200 |