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Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling

BACKGROUND: Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhib...

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Detalles Bibliográficos
Autores principales:	Due, Michael R, Piekarz, Andrew D, Wilson, Natalie, Feldman, Polina, Ripsch, Matthew S, Chavez, Sherry, Yin, Hang, Khanna, Rajesh, White, Fletcher A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519737/ https://www.ncbi.nlm.nih.gov/pubmed/22898544 http://dx.doi.org/10.1186/1742-2094-9-200

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