Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

BACKGROUND: NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II drug metabolizing/detoxifying genes through binding to the antioxidant response elements (ARE). NRF2-ARE signaling plays a central role in protecting cells from a wide spectrum of reactive toxic species inclu...

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Detalles Bibliográficos
Autores principales: Huang, Ying, Li, Wenge, Kong, Ah-Ng Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519783/
https://www.ncbi.nlm.nih.gov/pubmed/23190551
http://dx.doi.org/10.1186/2045-3701-2-40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519783/
https://www.ncbi.nlm.nih.gov/pubmed/23190551
http://dx.doi.org/10.1186/2045-3701-2-40

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