High Yield Production and Refolding of the Double-Knot Toxin, an Activator of TRPV1 Channels

A unique peptide toxin, named double-knot toxin (DkTx), was recently purified from the venom of the tarantula Ornithoctonus huwena and was found to stably activate TRPV1 channels by targeting the outer pore domain. DkTx has been shown to consist of two inhibitory cysteine-knot (ICK) motifs, referred...

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Detalles Bibliográficos
Autores principales: Bae, Chanhyung, Kalia, Jeet, Song, Inhye, Yu, JeongHeon, Kim, Ha Hyung, Swartz, Kenton J., Kim, Jae Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519854/
https://www.ncbi.nlm.nih.gov/pubmed/23240036
http://dx.doi.org/10.1371/journal.pone.0051516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519854/
https://www.ncbi.nlm.nih.gov/pubmed/23240036
http://dx.doi.org/10.1371/journal.pone.0051516

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