MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instabili...

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Detalles Bibliográficos
Autores principales: Savio, Andrea J., Lemire, Mathieu, Mrkonjic, Miralem, Gallinger, Steven, Zanke, Brent W., Hudson, Thomas J., Bapat, Bharati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519863/
https://www.ncbi.nlm.nih.gov/pubmed/23240038
http://dx.doi.org/10.1371/journal.pone.0051531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519863/
https://www.ncbi.nlm.nih.gov/pubmed/23240038
http://dx.doi.org/10.1371/journal.pone.0051531

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