Cargando…

MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instabili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savio, Andrea J., Lemire, Mathieu, Mrkonjic, Miralem, Gallinger, Steven, Zanke, Brent W., Hudson, Thomas J., Bapat, Bharati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519863/ https://www.ncbi.nlm.nih.gov/pubmed/23240038 http://dx.doi.org/10.1371/journal.pone.0051531

Ejemplares similares

The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer
por: Savio, Andrea J., et al.
Publicado: (2017)

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
por: Grandi, Fiorella C., et al.
Publicado: (2015)

CpG island shore methylation regulates caveolin-1 expression in breast cancer
por: Rao, X, et al.
Publicado: (2013)

Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization
por: Muse, Meghan E., et al.
Publicado: (2020)

Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer
por: Mrkonjic, Miralem, et al.
Publicado: (2010)

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer
por: Shigeyasu, Kunitoshi, et al.
Publicado: (2015)

Why is DNA methylation of Igf2 CpG island shore affected during ageing?
por: Caiafa, Paola, et al.
Publicado: (2012)

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
por: Chen, Yi-an, et al.
Publicado: (2013)

Subtype-specific CpG island shore methylation and mutation patterns in 30 breast cancer cell lines
por: Chae, Heejoon, et al.
Publicado: (2016)

DNA methylation ambiguity in the Fibrillin-1 (FBN1) CpG island shore possibly involved in Marfan syndrome
por: Arai, Yoshikazu, et al.
Publicado: (2020)

Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays
por: Kron, Ken, et al.
Publicado: (2009)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress
por: Bockmühl, Yvonne, et al.
Publicado: (2015)

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients
por: Mitsumori, Risa, et al.
Publicado: (2020)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Prognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
por: Joo, Young-Eun
Publicado: (2015)

Bidding the CpG island goodbye
por: Greally, John M
Publicado: (2013)

CpGIF: an algorithm for the identification of CpG islands
por: Sujuan, Ye, et al.
Publicado: (2008)

Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
por: Irizarry, Rafael A., et al.
Publicado: (2009)

Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway
por: Kim, Jung Ho, et al.
Publicado: (2016)

Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients
por: Fu, Tao, et al.
Publicado: (2016)

CpGPAP: CpG island predictor analysis platform
por: Chuang, Li-Yeh, et al.
Publicado: (2012)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers
por: Harten, Sarah K, et al.
Publicado: (2015)

CpG Island Mapping by Epigenome Prediction
por: Bock, Christoph, et al.
Publicado: (2007)

Orphan CpG islands as alternative promoters
por: Sarda, Shrutii, et al.
Publicado: (2017)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray
por: Huntriss, John, et al.
Publicado: (2015)

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern
por: Bellizzi, Dina, et al.
Publicado: (2013)

CpG Islands: Starting Blocks for Replication and Transcription
por: Prioleau, Marie-Noëlle
Publicado: (2009)

CpG island hypermethylation go circular (RNA)
por: Dragomir, Mihnea P., et al.
Publicado: (2018)

Intragenic CpG Islands and Their Impact on Gene Regulation
por: Cain, James A., et al.
Publicado: (2022)

Sequence determinants, function, and evolution of CpG islands
por: Angeloni, Allegra, et al.
Publicado: (2021)

CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection
por: Matsukura, S, et al.
Publicado: (2003)

The transcription activity of OTX2 on p16 expression is significantly blocked by methylation of CpG shore in non-promoter of lung cancer cell lines
por: Peng, Honghao, et al.
Publicado: (2023)

CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?
por: Han, Leng, et al.
Publicado: (2009)

In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size
por: Shyamala, Nivas, et al.
Publicado: (2022)

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome
por: Heisler, Lawrence E., et al.
Publicado: (2005)

CpGcluster: a distance-based algorithm for CpG-island detection
por: Hackenberg, Michael, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_jkcov954adg8b0j1ciceh1g5bd