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Intracellular Proton Access in a Cl(−)/H(+) Antiporter
Chloride-transporting membrane proteins of the CLC family appear in two distinct mechanistic flavors: H(+)-gated Cl(−) channels and Cl(−)/H(+) antiporters. Transmembrane H(+) movement is an essential feature of both types of CLC. X-ray crystal structures of CLC antiporters show the Cl(−) ion pathway...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519907/ https://www.ncbi.nlm.nih.gov/pubmed/23239938 http://dx.doi.org/10.1371/journal.pbio.1001441 |