Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions...

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Detalles Bibliográficos
Autores principales: Bradshaw, Angela C., Coughlan, Lynda, Miller, Ashley M., Alba, Raul, van Rooijen, Nico, Nicklin, Stuart A., Baker, Andrew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520007/
https://www.ncbi.nlm.nih.gov/pubmed/22626939
http://dx.doi.org/10.1016/j.jconrel.2012.05.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520007/
https://www.ncbi.nlm.nih.gov/pubmed/22626939
http://dx.doi.org/10.1016/j.jconrel.2012.05.025

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