Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

BACKGROUND: The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective for...

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Detalles Bibliográficos
Autores principales: Al-Daghri, Nasser M, Cagliani, Rachele, Forni, Diego, Alokail, Majed S, Pozzoli, Uberto, Alkharfy, Khalid M, Sabico, Shaun, Clerici, Mario, Sironi, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520752/
https://www.ncbi.nlm.nih.gov/pubmed/23153210
http://dx.doi.org/10.1186/1741-7015-10-140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520752/
https://www.ncbi.nlm.nih.gov/pubmed/23153210
http://dx.doi.org/10.1186/1741-7015-10-140

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