Cargando…

Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

BACKGROUND: The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Daghri, Nasser M, Cagliani, Rachele, Forni, Diego, Alokail, Majed S, Pozzoli, Uberto, Alkharfy, Khalid M, Sabico, Shaun, Clerici, Mario, Sironi, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520752/ https://www.ncbi.nlm.nih.gov/pubmed/23153210 http://dx.doi.org/10.1186/1741-7015-10-140

Ejemplares similares

Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
por: Al-Daghri, Nasser M., et al.
Publicado: (2017)

Evolutionary rates of mammalian telomere-stability genes correlate with karyotype features and female germline expression
por: Pontremoli, Chiara, et al.
Publicado: (2018)

Multiple Selected Changes May Modulate the Molecular Interaction between Laverania RH5 and Primate Basigin
por: Forni, Diego, et al.
Publicado: (2018)

Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations
por: Forni, Diego, et al.
Publicado: (2020)

A complex evolutionary relationship between HHV-6A and HHV-6B
por: Forni, Diego, et al.
Publicado: (2019)

Retraction to: A complex evolutionary relationship between HHV-6A and HHV-6B
por: Forni, Diego, et al.
Publicado: (2019)

The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses
por: Forni, Diego, et al.
Publicado: (2015)

Ancient Evolution of Mammarenaviruses: Adaptation via Changes in the L Protein and No Evidence for Host–Virus Codivergence
por: Forni, Diego, et al.
Publicado: (2018)

Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders
por: Mozzi, Alessandra, et al.
Publicado: (2017)

Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection
por: Mozzi, Alessandra, et al.
Publicado: (2020)

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses
por: Forni, Diego, et al.
Publicado: (2023)

Antigenic variation of SARS‐CoV‐2 in response to immune pressure
por: Forni, Diego, et al.
Publicado: (2020)

Evolutionary insights into host–pathogen interactions from mammalian sequence data
por: Sironi, Manuela, et al.
Publicado: (2015)

OASes and STING: Adaptive Evolution in Concert
por: Mozzi, Alessandra, et al.
Publicado: (2015)

Evolutionary Analysis Provides Insight Into the Origin and Adaptation of HCV
por: Forni, Diego, et al.
Publicado: (2018)

Dating the Emergence of Human Endemic Coronaviruses
por: Forni, Diego, et al.
Publicado: (2022)

The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy
por: Mozzi, Alessandra, et al.
Publicado: (2018)

Albuminoid Genes: Evolving at the Interface of Dispensability and Selection
por: Mozzi, Alessandra, et al.
Publicado: (2014)

Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human host
por: Forni, Diego, et al.
Publicado: (2021)

Natural Selection at the Brush-Border: Adaptations to Carbohydrate Diets in Humans and Other Mammals
por: Pontremoli, Chiara, et al.
Publicado: (2015)

Selective events at individual sites underlie the evolution of monkeypox virus clades
por: Molteni, Cristian, et al.
Publicado: (2023)

The evolutionary history of genes involved in spoken and written language: beyond FOXP2
por: Mozzi, Alessandra, et al.
Publicado: (2016)

Nonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related Flaviviruses
por: Sironi, Manuela, et al.
Publicado: (2016)

Origin and dispersal of Hepatitis E virus
por: Forni, Diego, et al.
Publicado: (2018)

Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins
por: Sironi, Manuela, et al.
Publicado: (2018)

Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2
por: Cagliani, Rachele, et al.
Publicado: (2020)

Coding potential and sequence conservation of SARS-CoV-2 and related animal viruses
por: Cagliani, Rachele, et al.
Publicado: (2020)

Molecular Evolution of Human Coronavirus Genomes
por: Forni, Diego, et al.
Publicado: (2017)

Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns
por: Sironi, Manuela, et al.
Publicado: (2006)

The landscape of human genes involved in the immune response to parasitic worms
por: Fumagalli, Matteo, et al.
Publicado: (2010)

Genome-Wide Identification of Susceptibility Alleles for Viral Infections through a Population Genetics Approach
por: Fumagalli, Matteo, et al.
Publicado: (2010)

Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs
por: Al-Daghri, Nasser M, et al.
Publicado: (2013)

Past and ongoing adaptation of human cytomegalovirus to its host
por: Mozzi, Alessandra, et al.
Publicado: (2020)

Decreasing Prevalence of the Full Metabolic Syndrome but a Persistently High Prevalence of Dyslipidemia among Adult Arabs
por: Al-Daghri, Nasser M., et al.
Publicado: (2010)

Simplexviruses Successfully Adapt to Their Host by Fine-Tuning Immune Responses
por: Mozzi, Alessandra, et al.
Publicado: (2022)

The substitution spectra of coronavirus genomes
por: Forni, Diego, et al.
Publicado: (2021)

Alternation between taxonomically divergent hosts is not the major determinant of flavivirus evolution
por: Pontremoli, Chiara, et al.
Publicado: (2021)

Monkeypox virus: The changing facets of a zoonotic pathogen
por: Forni, Diego, et al.
Publicado: (2022)

Genetic ancestry and population structure of vaccinia virus
por: Molteni, Cristian, et al.
Publicado: (2022)

Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records
por: Forni, Diego, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p3mdk1fe8uckm4adv8ifvva52c