Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening

BACKGROUND: Much is written about cognitive and motor development; less is known about social and emotional consequences of growing up with congenital hypothyroidism (CH). The objectives of the study were: (1) to compare health related quality of life (HRQoL) and self-worth of 10 year old patients w...

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Autores principales: van der Sluijs Veer, Liesbeth, Kempers, Marlies JE, Maurice-Stam, Heleen, Last, Bob F, Vulsma, Tom, Grootenhuis, Martha A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520758/
https://www.ncbi.nlm.nih.gov/pubmed/23034129
http://dx.doi.org/10.1186/1753-2000-6-32
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author van der Sluijs Veer, Liesbeth
Kempers, Marlies JE
Maurice-Stam, Heleen
Last, Bob F
Vulsma, Tom
Grootenhuis, Martha A
author_facet van der Sluijs Veer, Liesbeth
Kempers, Marlies JE
Maurice-Stam, Heleen
Last, Bob F
Vulsma, Tom
Grootenhuis, Martha A
author_sort van der Sluijs Veer, Liesbeth
collection PubMed
description BACKGROUND: Much is written about cognitive and motor development; less is known about social and emotional consequences of growing up with congenital hypothyroidism (CH). The objectives of the study were: (1) to compare health related quality of life (HRQoL) and self-worth of 10 year old patients with CH with the general population; (2) to explore associations of disease factors, IQ and motor skills with the outcomes. METHODS: Children with CH and their parents completed several questionnaires. Patients were classified to ‘severe CH, n = 41’ or ‘moderate/mild CH, n = 41’ based on pre-treatment FT4 concentration. Differences between CH and the general population were tested by analysis of covariance and one sample t-tests (mean scale scores HRQoL and self-worth), chi-square tests and binomial tests (% at risk of impaired HRQoL and self-worth). Linear regression analyses corrected for gender were conducted to explore associations of the outcomes with disease factors, IQ and motor skills. RESULTS: Patients with CH reported lower mean HRQoL on motor, cognitive and social functioning, and on autonomy and positive emotions (p < 0.0001). Patients were also more often at risk for impaired HRQoL and self-worth. No differences were found between the severity groups. Lower IQ was only significant associated with worse cognitive HRQoL. Initial FT4 plasma, age at onset of therapy, initial T4 dose and motor skills were not significantly associated with HRQoL and self-worth. CONCLUSIONS: Negative consequences in terms of HRQoL and self-worth are prevalent in children with CH, independent of disease factors, IQ and motor skills. Physicians should to be attentive to these consequences and provide attention and supportive care.
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spelling pubmed-35207582012-12-13 Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening van der Sluijs Veer, Liesbeth Kempers, Marlies JE Maurice-Stam, Heleen Last, Bob F Vulsma, Tom Grootenhuis, Martha A Child Adolesc Psychiatry Ment Health Research BACKGROUND: Much is written about cognitive and motor development; less is known about social and emotional consequences of growing up with congenital hypothyroidism (CH). The objectives of the study were: (1) to compare health related quality of life (HRQoL) and self-worth of 10 year old patients with CH with the general population; (2) to explore associations of disease factors, IQ and motor skills with the outcomes. METHODS: Children with CH and their parents completed several questionnaires. Patients were classified to ‘severe CH, n = 41’ or ‘moderate/mild CH, n = 41’ based on pre-treatment FT4 concentration. Differences between CH and the general population were tested by analysis of covariance and one sample t-tests (mean scale scores HRQoL and self-worth), chi-square tests and binomial tests (% at risk of impaired HRQoL and self-worth). Linear regression analyses corrected for gender were conducted to explore associations of the outcomes with disease factors, IQ and motor skills. RESULTS: Patients with CH reported lower mean HRQoL on motor, cognitive and social functioning, and on autonomy and positive emotions (p < 0.0001). Patients were also more often at risk for impaired HRQoL and self-worth. No differences were found between the severity groups. Lower IQ was only significant associated with worse cognitive HRQoL. Initial FT4 plasma, age at onset of therapy, initial T4 dose and motor skills were not significantly associated with HRQoL and self-worth. CONCLUSIONS: Negative consequences in terms of HRQoL and self-worth are prevalent in children with CH, independent of disease factors, IQ and motor skills. Physicians should to be attentive to these consequences and provide attention and supportive care. BioMed Central 2012-10-03 /pmc/articles/PMC3520758/ /pubmed/23034129 http://dx.doi.org/10.1186/1753-2000-6-32 Text en Copyright ©2012 van der Sluijs Veer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
van der Sluijs Veer, Liesbeth
Kempers, Marlies JE
Maurice-Stam, Heleen
Last, Bob F
Vulsma, Tom
Grootenhuis, Martha A
Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title_full Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title_fullStr Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title_full_unstemmed Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title_short Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
title_sort health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520758/
https://www.ncbi.nlm.nih.gov/pubmed/23034129
http://dx.doi.org/10.1186/1753-2000-6-32
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