Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography

BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariquidar on the pharmacokinetics of P-gp substrate radiotracer (R)-[(11)C]verapamil in plasma and brain of rats and humans by means of positron emission tomography (PET). METHODS: Data obtained from a preclinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Müllauer, Julia, Kuntner, Claudia, Bauer, Martin, Bankstahl, Jens P, Müller, Markus, Voskuyl, Rob A, Langer, Oliver, Syvänen, Stina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520775/
https://www.ncbi.nlm.nih.gov/pubmed/23072492
http://dx.doi.org/10.1186/2191-219X-2-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520775/
https://www.ncbi.nlm.nih.gov/pubmed/23072492
http://dx.doi.org/10.1186/2191-219X-2-58

Ejemplares similares